calcificationEnglishOxford New American Dictionarycalcification /ˌkalsəfəˈkāSH(ə)n, ˌkælsəfəˈkeɪʃ(ə)n / ▸ noun the hardening of tissue or other material by the deposition of or conversion into calcium carbonate or some other insoluble calcium compounds: there is calcification in the right shoulder causing soreness.