macrocyclicEnglishOxford New American Dictionarymacrocyclic /ˌmakrōˈsīklik, ˌmækroʊˈsaɪklɪk / ▸ adjective Chemistry relating to or denoting a ring composed of a relatively large number of atoms, such as occurs in heme, chlorophyll, and several natural antibiotics. – DERIVATIVES macrocycle /ˈmakrōˌsīkəl/ noun