macro-EnglishOxford New American Dictionarymacro- /ˈmakrō, ˈmækroʊ / ▸ combining form 1 large; large-scale: macromolecule macronutrient. ▪ (used in medical terms) large compared with the norm: macrocephaly. 2 long; over a long period: macroevolution. – ORIGIN from Greek makros ‘long, large’.