Englishvicissitude
noun
he maintains his sunny disposition despite life's vicissitudes:
change, alteration, alternation, transformation, metamorphosis, transmutation, mutation, modification, transition, development, shift, switch, turn;
reversal, reverse, downturn;
inconstancy, instability, uncertainty, unpredictability, chanciness, fickleness, variability, changeability, fluctuation, vacillation;
ups and downs.