manicEnglishOxford American Thesaurusmanic adjective 1 a manic grin: mad, insane, deranged, demented, maniacal, lunatic, crazed, wild, demonic, demoniacal, hysterical, raving, neurotic, unhinged, unbalanced; British sectionable; informal crazy. ▷antonyms sane. 2 scenes of manic activity: frenzied, feverish, frenetic, hectic, intense; informal hyper, mad; British, informal swivel-eyed. ▷antonyms calm.