fatalEnglishOxford American Thesaurusfatal adjective 1 a fatal disease: deadly, lethal, mortal, causing death, death dealing, killing; final, terminal, incurable, untreatable, inoperable, malignant; tragic; literary deathly; archaic baneful. ▷antonyms harmless; superficial. 2 don't make the fatal mistake of assuming others think as you do: disastrous, devastating, ruinous, catastrophic, calamitous, cataclysmic, destructive, grievous, dire, crippling, crushing, injurious, harmful, costly; literary direful. ▷antonyms harmless; beneficial.