calamity

noun

the fire was only the latest calamity to strike the area:

disaster, catastrophe, tragedy, cataclysm, devastating blow, crisis, adversity, blight, tribulation, woe, affliction, evil;

misfortune, misadventure, accident, stroke of bad luck, reverse of fortune, setback, mischance, mishap;

British, informal car crash;

archaic bale;

Scottish, archaic mishanter.

▷antonyms godsend, blessing.